Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study

Chronic lung allograft dysfunction following lung transplantation: challenges and solutions

Prediction of chronic lung allograft dysfunction: a systems medicine challenge.

Affiliations: Clinique Universitaire de Pneumologie, Pôle de Cancérologie, Médecine Aiguë et Communautaire, CHU Grenoble, Inserm1055, Grenoble, Université Joseph Fourier, Grenoble, European Institute for Systems Biology and Medicine, EISBM, Lyon, Institut du Thorax, Inserm UMR1087, CNRS UMR629, Service de Pneumologie, CHU de Nantes DHU2020, Nantes, Université de Nantes, Nantes, Université Josep...

Lung function effects of chronic exposure to air pollution.

Lung function is an excellent operative marker of the effects of air pollution in the general population. It is objective and quantitative, an early predictor of cardiorespiratory morbidity and mortality, able to describe trajectories to the occurrence of chronic obstructive pulmonary disease (COPD) and coherent with experimental data on deposition and accumulation of pollutants in airways and ...

Mechanistic differences between phenotypes of chronic lung allograft dysfunction after lung transplantation

Distinct phenotypes of chronic lung allograft dysfunction (CLAD) after lung transplantation are emerging with lymphocytic bronchiolitis (LB)/azithromycin reversible allograft dysfunction (ARAD), classical or fibrotic bronchiolitis obliterans syndrome (BOS), and restrictive allograft syndrome (RAS) proposed as separate entities. We have additionally identified lung transplant recipients with pri...

Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation

CD59 is a complement regulatory protein that inhibits membrane attack complex formation. A soluble form of CD59 (sCD59) is present in various body fluids and is associated with cellular damage after acute myocardial infarction. Lung transplantation (LTx) is the final treatment for end-stage lung diseases, however overall survival is hampered by chronic lung allograft dysfunction development, wh...